Our comprehensive aesthetic injectable comparison chart is your essential tool. It puts into perspective leading products from Juvéderm (cross-linked hyaluronic acid) to Profhilo (bioremodeling), including Teosyal (dynamic hyaluronic acid) and Ellansé (PCL), to guide you toward the optimal injection protocol for effective neocollagenesis and natural-looking results. Which injectable component should you choose for your patients?
Comparison of Leading Aesthetic Injectables: A Guide for Practitioners
As an aesthetic physician, the range of injectable therapies is constantly expanding, making the choice of a filler or biostimulation strategy increasingly complex. On France-Health, we break down the fundamental differences between leading brands and cutting-edge technologies. The era of Hyaluronic Acid (HA) alone is over: today, hybrid fillers and Biostimulators based on PLLA (Sculptra, Lanluma) or CaHA (Radiesse, Harmonyca) dominate the market.
|
Main Active Constituent |
Leading Brands (Examples) |
Targeted Action & Mechanism |
Estimated Duration (Average) |
FOCUS |
|
Cross-linked Hyaluronic Acid (HA) |
JUVÉDERM (VYCROSS®, HYLACROSS®), STYLAGE (IPN-Like®) |
Filling and Volumization. Corrects wrinkles (nasolabial folds, marionette lines) and restores deep facial volume. Immediate effect. |
6 to 18 months |
HA Filler Volumization Wrinkle Filling AH Technology |
|
Cross-linked Hyaluronic Acid (HA) |
RESTYLANE (NASHA®/OBT® Tech), SAYPHA (Croma) |
Filling and Definition. OBT Technology allows targeted tissue integration for defined lips to deep volume. |
6 to 18 months |
Restylane Galderma Filler HA Filling AH Viscosity |
|
Dynamic Hyaluronic Acid (RHA AH) |
TEOSYAL(RHA® Technology) |
Filling and Dynamism. RHA (Resilient Hyaluronic Acid) adapts to facial movement. Key product: Redensity 2 (tear troughs/undereyes). |
9 to 18 months |
Teosyal RHAFiller Tear Trough Dynamic Filling |
|
Calcium Hydroxylapatite (CaHA) |
RADIESSE, HARMONYCA (CaHA + Cross-linked HA) |
Volumization and Biostimulation. Immediate filling effect followed by strong, long-lasting stimulation of collagen production (neocollagenesis). |
12 to 18 months |
Biostimulator CaHA Radiesse Collagen Stimulation |
|
Polycaprolactone (PCL) |
ELLANSÉ (CMC Carrier Tech) |
Biostimulation and Long-lasting. CMC gel provides initial volume; PCL microspheres slowly biodegrade, stimulating collagen production. |
12 months to 4 years (depending on version) |
Ellanse PCLFiller Collagen Inducer Long Lasting |
|
Poly-L-Lactic Acid (PLLA) |
LANLUMA, SCULPTRA (Galderma) |
Pure and Progressive Biostimulation. Microparticles induce gradual neocollagenesis, restoring skin firmness and thickness. |
Up to 2 years (after protocol) |
Lanluma PLLA Sculptra Skin Regeneration |
|
HA + Polyrevitalizing Ingredients |
FILLMED NCTF 135HA |
Mesotherapy/Polyrevitalization.Non or very weakly cross-linked HA (5 mg/ml) combined with 59 active ingredients (vitamins, amino acids, etc.) for radiance and dermal density. |
Requires regular courses |
Mesotherapy Polyrevitalization NCTF Skin Quality |
|
HA (26 mg/ml) Cross-linked with PEG + CaHA (1%) |
NEAUVIA (Stimulate) |
Filling and Synergistic Biostimulation. Combines the volumizing effect of PEG-cross-linked HA with a low dose of CaHA (1%) for deep collagen stimulation. |
12 to 18 months |
Neauvia AH CaHA Hybrid Filler Advanced Biostimulation |
|
Hybrid AH (High & Low MW) Ultra-pure |
PROFHILO (IBSA) |
Bioremodeling. Stabilized HA without a cross-linking agent (BDDE). Aims to remodel tissue architecture and improve elasticity/hydration without traditional volume. |
6 to 9 months (after 2 initial sessions) |
Profhilo Bioremodeling Cellular Hydration Skin Firming |
|
HA + CT50 Rejuvenating Complex |
CYTOCARE (CT50) |
Mesotherapy/Cellular Revitalization. Non-cross-linked HA combined with a complex of amino acids, vitamins, and minerals for hydration, antioxidation, and radiance (Meso-Cocktail). |
Requires regular courses |
Cytocare MesoTherapy Rejuvenating Complex Radiance |
|
HA VITAL Skinbooster (Non-Cross-linked) |
RESTYLANE VITAL Skinboosters |
Deep Hydration (Skinbooster).Very fluid HA, superficially injected, to improve skin elasticity, texture, and overall hydration. |
6 to 9 months (after initial protocol) |
Skinbooster DeepHydration VitalSkin SkinTexture |
Conclusion for Professionals
This table clearly illustrates that the choice of an injectable depends on the therapeutic objective:
- For Immediate Volume and Filling: Focus on Cross-linked Hyaluronic Acids (Juvéderm, Restylane, Teosyal).
- For Regeneration and Lasting Firmness: Opt for Biostimulators (Radiesse, Ellansé, Lanluma, Sculptra).
- For Skin Quality and Hydration: Favor Mesotherapy and Skinboosters (NCTF 135HA, Cytocare, Volite, Profhilo).
This filler selection guide clearly demonstrates that there is no single "best" injectable for everyone, but rather the most relevant solution for each specific indication. For immediate volume, cross-linked hyaluronic acid (Juvéderm, Stylage) remains the gold standard. However, to treat skin laxity and achieve lasting tissue regeneration, biostimulation with PLLA or CaHA is essential.
Synergic treatments: combining a hyaluronic acid filler for structure with a biostimulator or skin booster (Vital, NCTF 135HA) for skin quality is the key to successful rejuvenation.
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